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What are the Best Nootropics?

Nootropics also known as cognitive enhancers, brain-boosters and smart drugs, are compounds or substances that improve mental performance and cognitive function like critical thinking, ability to focus and more.

To be considered on the list of the best Nootropics, a cognitive enhancer should have a track record of results which are clinically-proven to have properties that enhance cognition. There are numerous ways to improve how our brain function, several of which have substantial risks, so it is best to look at it on a case to case basis. The efficacy of Nootropics have little clinical figures that exists and the information we have so far are from collected anecdotal accounts. Still, based on the survey from people who have taken these smart drugs for years, here's the list of the Best Nootropics available on the market today.

  • Noopept

This is your daily Nootropic. The components of Noopept have been shown to enhance memory, stamina, and focus. Most of the time, Noopept is directly associated with the Racetam family of Nootropics but it is much more powerful. This synthetic drug increases learning and retaining information, stimulates the mind, improve memory formation as well as focus and memory formation.

  • Phenibut

Known to help anxiety and depression, Phenibut offers many anxiolytic benefits, reducing stress and improving a person’s mood and emotional well-being. It is reported to help encourage deep sleep, increasea focus levels, reduces anxiousness and stress, and also increases sociability. A lot of people take it as a sleep aid or to help them relax and decompress when they are experiencing episodes of nervousness and high anxiety.

  •  Smart V2                         

This everyday Nootropic is by far one of the most rated cognitive enhancers out there. Smart V2 has been formulated with the most premium Nootropic ingredients, making it one of the most sought after “Smart Nootropics” on the market. It improves learning by stimulating and energizing brain receptors, lowers brain fog resulting in increased motivation and focus, supports advanced cognitive function as well as increases attention to details and sharpness of mind. If you’re in need of a Nootropic and you’re not sure exactly where to start, here’s the best you can get.

  • Oxiracetam

Oxiracetam helps in the improvement of memory, especially long-term memory and recall. This compound is part of the racetam family but is more potent than Piracetam. This supplement has also shown to offer a very powerful mental stimulation, helps reduce the rate or organic cognitive decline, and helps improve overall cognition as well as improve concentration, focus and motivation.

  • Pramiracetam

Another part of the racetam family, Pramiracetam is also one of the most sought after Nootropic today for improving memory, learning capacity, improving brain function and enhancing focus. The brain’s performance is optimized through the increase on the activity of the neurotrasmitters.

  • CDP-Choline

This is a potent Nootropic and shows the ability to potentially reduce certain amounts of fat within our liver. Choline is important for our brains to function properly and plays a crucial role in several cognitive processes such as those integral to memory learning, capacity and reasoning. This supplement also boost overall cognition, memory function and helps address problems with fatigue.


Are Nootropics Legal?

The legality of Nootropics is often a confusing one. Since it affects how human brain works and process, the question of whether it is a legal substance or not is common among the Nootropics online community. There are virtually hundreds of these smart drugs or cognitive enhancers currently available that promise benefits such as enhancing cognition, alertness, mood and memory. Certainly, if a specific substance alter our cognitive processes, one will have a good reason to be suspicious about its legal implications.

History of Nootropics

Nootropics is a term coined by Romanian biochemist, Dr. Corneliu Giurgea, the man behind the development of Piracetam, the first synthesized smart drug, in 1964. Back then he was working for a Belgium-based international pharmaceutical company called UCB. Dr. Giurgea was astounded at Piracetam’s cognitive enhancing properties, he then refer to these kinds of substances as Nootropic. In addition, for compounds and substances to be characterized as Nootropics, he set the abilities and standards for them.  According to Dr. Giurgea, the properties of Nootropics should include the following:

  • Improves learning abilities and memory functions.
  • Capability to protect human brains from injury.
  • It’s not toxic and have no side effects that can harm an individual.
  • Ability to protect learned abilities and encoded memories against the conditions that affect them adversely.
  • It does not have psychotropic effects of any kind.

So is it legal?

If we are to base on the standards above, it is safe to say that Nootropics should therefore be legal if it will follow and measure up to the standards set forth by Dr. Giurgea. But, there are distributors and manufacturers who used the term indiscriminately to refer stimulants, amphetamines and any other type of substances and compounds that are potentially toxic, have a high probability for abuse and very harmful.

As most of us know, each country has its own sets of laws and the definition of Nootropic varies from country to country as well.  Furthermore, there are regulatory agencies in a country which do not even use the term Nootropic.

Here at Nootrostax, we define these cognitive enhancing drugs as specialized compounds which include various vitamins, minerals and amino acids designed to improve cognitive function and mental performance. There are also smart drugs like Modafinil, Adderall and Ritalin which are stimulants used in treating narcolepsy, ADHD and other medical conditions which usually requires a doctor’s prescription to obtain.

Nootropic’s legality in numerous countries like the UK fall in what we can call a gray area. In the US, selling Nootropics are not as restricted and most are sold legally as dietary supplements. An individual can purchase or possess Nootrostax Smart without requiring a prescription. While there are Nootropics that may be legal in some countries, customs mays sometimes decide that they are not fit for import. There are times when small quantities are allowed for import as long as it is intended for personal use.

In conclusion, the legality of Nootropics is highly dependent on your country of origin, even in free trade zones or unions like the EU. In countries like the UAE, a lot of medications for ADHD are illegal and in Australia they consider Piracetam as poisonous. If you’re planning on ordering Nootropics online, make sure to do your research regarding your custom’s food and drugs policy.


What are Nootropics?

About the Writer:

R Elcoli holds a Master of Science (M.S.) in Biomedical Science and a Bachelor of Science (B.S.) in Biomedical Laboratory Sciences and is an avid medical writer. 

Nootropics are a class of cognitive enhancing drugs that improve concentration and boost memory and are often used to increase attention spans, help individuals focus and as studying aids. Nootropics are referred to as smart drugs, memory enhancers, neuron-enhancers, cognitive enhancers, and intelligence enhancers, motivational, and stress management as they are associated with increased intelligence, motivation, and mental energy. Nootropics are broadly any type of neuro-enhancing drug with very low prevalence of side effects.

Nootropics are used for increasing information processing and applying knowledge. They involve memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics was coined in 1972 when memory enhancing properties of Piracetam were observed in clinical trials. In the meantime, hundreds of drugs have been evaluated in clinical trials.

The concept and definition of a "nootropic drug" was first proposed by C.E. Guirgea, the principal Piracetam researcher. He coined the term"nootropic" from the italic words "noos" (mind) and "tropein" (to turn toward), to mean enhancement of learning and memory. The main features defining a nootropic drug are:

The Defining Features of Nootropics

  1. The enhancement of learning and memory acquisitions as well as the resistance to agents that to impair learning and cognitive development.
  2. Protection of brain against various physical or chemical injuries.
  3. Flow facilitation for information and efficient tonic cortical/subcortical mechanism.
  4. The absence of negative pharmacologic effects of psychotropic drugs.

How do Nootropics work?

Nootropics have actually been found as one of the reliable supplements for the mind; for that reason, its relevance has actually additionally led folks in the renovation of their memory as well as finding out ability or intellectual procedures.

Nootropics release or respond to acetylcholine. By increasing high-affinity choline uptake, these drugs facilitate acetylcholine production and turnover with varying actions at both muscarinic and nicotinic receptors.

Nootropics shows signs of neuro-preservation and neuro-protection. These compounds directly affect the level of neurotransmitters associated with slowing down the aging process. Nootropics elevate the density of frontal cortex acetylcholine receptors by 30- 40% restoring the levels of acetylcholine in the brain. Energy (ATP) is critical to the brain's very survival and brain cells must produce all their own ATP from glucose (sugar) and oxygen. They cannot borrow ATP from other cells. Brain carbohydrate metabolism is impaired in a variety of dementias and the degree of reduction in brain carbohydrate metabolism correlated with the severity of the dementia. Nootropics increase the activity of adenylate kinase enzyme that converts ADP into ATP and AMP.

Nootropics increase cerebral blood flow, cerebral oxygen usage metabolic rate and cerebral glucose metabolic rate in chronic impaired human brain function i.e., multi-infarct (stroke) dementia, senile dementia of the Alzheimer type and pseudo dementia, ischaemic cerebral (poor brain blood flow) infarcts. They reduce the platelet aggregation and have haemorrheological and antithrombotic effects. They also change the physical properties of membranes, and enhance membrane fluidity, presumably by binding to membrane phospholipids.

Nootropics improve red blood cell function, decrease the adherence of damaged and sickle cell red blood cells to the endothelium, increases prostacyclin (PGI2) production and activity, enhances phospholipids - metabolism and protein biosynthesis.

What are the benefits of Nootropics?

Nootropics can boost cognitive functioning. They can make you think better, faster, and even help you perform better on an IQ test.

Specific effects can include improvements to working memory, motivation, or attention. These drugs are purportedly used primarily to treat cognitive or motor function difficulties attributable to disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and ADHD.

While scientific studies support the beneficial effects of many nootropic compounds, manufacturer's marketing claims for dietary supplements are usually formally tested and verified by independent entities.

Nootropics are created to enhance our psychological capabilities and improve our social abilities.

Nootropics have been used to increase the productivity. Several factors positively and negatively influence the use of nootropics to increase cognitive performance specific effects can include improvement to working memory. Some nootropics will result in an increase in production of brains cells while slowing down their destruction as well.

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